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Huntington’s Disease

Huntington’s disease has autosomal dominant inheritance, which means that an individual needs only one copy of the defective gene to develop the disorder. In this type of inheritance pattern, each offspring of an affected individual will have a 50% risk of inheriting the mutant allele and being affected with the disorder. The inheritance is independent of gender, and the phenotype does not skip generations. Huntington’s disease usually causes cognitive, movement and psychiatric disorders with a large variation of signs and symptoms. Some of the disorders may appear to be more dominant or have a greater effect on the functional ability of an individual. When the altered gene is passed from one generation to the next, mutant allele often increases in size and a larger number of repeats is usually associated to with an earlier onset of signs and symptoms.

Refrences:

http://www.mayoclinic.org/diseases-conditions/huntingtons-disease/symptoms-causes/dxc-20321436

https://en.wikipedia.org/wiki/Huntington%27s_disease#Inheritance

https://ghr.nlm.nih.gov/condition/huntington-disease#inheritance