Mutation Story – Alzheimer’s

Here is my Mutation story:

My video was unable to upload because the size exceeds the limits! ( I will present the video to Mr. Robinson in class)

This is my script/paragraphs from Part 1 as well as my “Making of the Mutation Story” (Part 2):

Mutation Story – Alzheimer’s disease:

Let’s start at the core of the problem by understanding your cells “Blueprints” so you will be able to see the reasoning behind how your genetic mutation works. Imagine your cell filled with all its essential parts, actually let’s take a trip even deeper… Pretend you are a little nucleotide. What’s that you ask, well I’ll explain soon enough! Inside your nucleus you have 46 chromosomes 23 from each parent and in each chromosome you have DNA and genes. Genes are what make up your physical attributes such as blue eyes and brown hair. DNA is the long strand, almost 6 feet, that is made up of nucleotides; A, T, C, G. Nucleotides are the molecules that make up your DNA which can be found attached to a phosphate sugar backbone. As well as being a long “strand” DNA’s function is to send coded messages or sequences out to our body, so we function properly. After that there is RNA that takes a copy of DNA and turns it into protein. That was the simple version, I know but here’s where it gets even more complicated. That was a description of a normal cell’s nucleus but one with a genetic disorder is even more difficult to grasp.

Imagine you live in a huge town filled with houses 23 are blue 23 are red, the houses represent the 46 chromosomes in the nucleus in each little chromosome house there are DNA and genes living inside. But what happens if one of the family members decides to move away or gets “sick” (mutation), bring someone new home, swaps with a friend?! Any of these would cause some sort of mutation in your cell. For the genetic disorder Alzheimer’s house #21, 14, or 1 have someone sick in their house. For the story I will choose house number 14 is the chromosomes who has a sick Nucleotide (family member).

That is where the mutation starts, there are two types of Alzheimer’s early on-set and late on-set they’re both genetic only early on-set can start having effects on your brain in your 30-60’s and late on-set will effect you in your 60’s and later. In our story we said house 14 has a sick member that causes the mutation of Alzheimer’s. For chromosomes 14 the mutation causes a abnormal presenilin 1 to be made which causes a ripple effect. If your DNA has a mutation, then when your RNA (copy) is made it will take the mutation with it. This causes abnormal proteins to be created which creates a malfunction in the sequenced message sent to your brain.

Now we are starting to talk about how this effects its host well it does quite a bit. In early and late on-set they have the same symptoms the only difference is in late on-set they are still researching which gene causes it. What happens to the person is; they begin to have symptoms similar to dementia but don’t be mistaken dementia and Alzheimer’s are different disorders. The most seen effects are; memory loss, impaired thinking, disorientation, changes in personality and mood and sometimes behavioral problems.

Scientifically what happens is the messages from the RNA are mangled and can’t get to the brain similar to the messages being tied off. The DNA is mutated which causes plaques and tangles in the brain tissue both of which are toxic. This kills the brain tissue and the living cells inside the brain which causes the size in some regions of the brain to shrink sufficiently. Throughout time the brain tissue continues to shrink which increases the amount and severity of the symptoms listed.

Patients who develop Alzheimer’s at the age of 65 tend to live 8.3 years longer while patients who developed it around 90 live up to 3.4 years after. After seeing how quickly this disease deteriorates the brain what are some cures or treatments? Because Alzheimer’s is connected to dementia there are experimental dementia treatments that can slow down the process similar to Alzheimer’s. There is no “cure” for Alzheimer’s… Yet but they are experimenting and doing new innovative trials to slow down problems in their brains. Of course, there are also drug and organic ways to help with the behavioral problems as well. Knowing there is no cure is sad but gives hope that they are trying to find new ways and solutions to fix concerning problems!

  • When does the average person with Alzheimer’s first start to see side effects of the genetic disorder?
  • What genes are affected by this disorder?
  • What happens to you as gene?
  • What causes the Alzheimer mutation?
  • What effects did the gene mutation have on your host’s body?
  • How was the host’s life affected? What was their story?
  • Where are chromosomes, genes etc. in the cell?
  • Is there more than one type of Alzheimer’s?
  • How does the disorder affect your brain health and the signals sent to your brain?

 

Bibliography :

  1. http://www.alzheimer.ca/en/Home/About-dementia/Alzheimer-s-disease?gclid=EAIaIQobChMInuriroi_2AIVh6_sCh2zcwR3EAAYASAAEgLJuvD_BwE

Website Title: Alzheimer’s disease | Alzheimer Society of Canada

Article Title: Alzheimer’s disease

Date Accessed: January 04, 2018

  1. https://www.merriam-webster.com/dictionary/Alzheimer%27s

Website Title: Merriam-Webster

Article Title: Alzheimer’s

Publisher: Merriam-Webster

Date Accessed: January 04, 2018

  1. https://www.nia.nih.gov/health/alzheimers-disease-genetics-fact-sheet

Website Title: National Institute on Aging

Article Title: Alzheimer’s Disease Genetics Fact Sheet

Publisher: U.S. Department of Health and Human Services

Date Accessed: January 04, 2018

  1. http://www.bbc.com/news/health-28262878

Website Title: BBC News

Article Title: One in three Alzheimer’s cases preventable, says research[…]

Publisher: BBC

Electronically Published: July 14, 2014

Date Accessed: January 04, 2018

  1. https://www.healthline.com/health/alzheimers-disease/life-expectancy

Website Title: Healthline

Article Title: The Facts About Alzheimer’s: Life Expectancy and Long-Te[…]

Publisher: Healthline Media

Date Accessed: January 04, 2018

  1. https://www.alz.org/alzheimers_disease_treatments.asp

Website Title: Alzheimer’s Association

Article Title: Latest Treatment Options

Date Accessed: January 04, 2018

  1. http://www.startstemcells.com/dementia-treatment.html?gclid=EAIaIQobChMIls2F0ay_2AIVhfhkCh24ewtSEAAYASAAEgIgQ_D_BwE

Website Title: Dementia treatment with stem cells

Article Title: Dementia – Stem cells treatment clinic

Date Accessed: January 04, 2018

 

  • What new or familiar digital tools did you try to use as you worked through this project?

I not only researched online using google and watching brief explanation videos on YouTube but in the end, I used a new site called “Easy Bib” to site all my resources. Also, I used iMovie to edit and put together my video, adding music and changing effects to make it as engaging as possible.

  • What was the process you used to investigate the topic?

I followed my research questions and followed each lead the questions gave me staying on track with the story all at once. I also assured to get all the facts down and into the story.

  • How did you verify and cite the information you found?

I used Easy Bib which I know is a valid cite because my teachers in grade 8 and 9 recommended it for use.

  • How did the process of completing this challenge go? What could you have done better?

I thought I completed the challenge well fulfilling my personal goals of using a new program on my own (iMovie) and overcoming the challenges of the research and finding the most pertinent information needed. Something I could’ve done better was having smoother transitions throughout the video and I could’ve started the project earlier into the break and done it over the two weeks instead of a few days.

 

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