Posts Tagged ‘ADL16Mutation’

Mutation Story

Part 1 (Mutation Story) 

Hello! I am a gene inside of Riley’s body. Riley has a genetic disorder called Sickle-Cell disease. I was inherited from Riley’s parents. The reason that she has Sickle-Cell disease is caused by a genetic abnormality in the gene for hemoglobin. When oxygen is released from hemoglobin, it sticks all together and forms long crescent rods that damage and change the shape of the red blood cells. Riley got this disease from sickle hemoglobin genes that were from both of her parents. Mutations in the hemoglobin beta gene on chromosome 11 caused Riley to have this genetic disorder. Faults that Riley has had due to this disease is damage to her spleen, kidneys and liver. She also has delayed growth and vision problems which make it difficult for her to get along with kids her age. Riley’s genetic disorder didn’t appear until she was four months old. She will most likely only live until her late 40’s to early 50’s and also has an increased risk of arthritis, anemia, leg ulcers and heart injury.

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Part 2 (The making of Mutation story)

Ask – What is Sickle-Cell disease? How does it form in a person’s body? Where does the disease come from? Can it be cured? What happened to the genes? What are risks of having Sickle-Cell disease?

Aquire – The digital tools that I used were all modern, familiar and resourceful. I used my IPad to look up useful and resourceful websites and I used a piece of paper and pencil to write down all of the information that I found on Sickle-Cell disease. I also used pictures to show what this genetic disease looks like and how it works.

Analyze/Apply – The process I used was simple and direct. First, I looked up all of the information that I needed on several different websites. Then I cited all of the websites to make sure the information was correct and after I found all of the information that I needed, I wrote notes down on my paper and then put the story onto my Edublog.

Assess – I think the process went well. I finished the assignment on time and didn’t procrastinate the night before it was due. Over the process, I learned more about genes, abnormalities in genes and Sickle-Cell disease. I learned how it all works and forms in a person’s body. Next time, I will show more photos to describe the disease and state more information about what happens to the genes. I will also talk more about her main story. I really enjoyed this assignment and had fun learning about Sickle-Cell disease and genetic mutations.

Websites: 

http://www.webmd.com/pain-management/pain-management-sickle-cell-disease

https://www.genome.gov/10001219/learning-about-sickle-cell-disease

http://www.nejm.org/abi/full/10.1056/NEJM199406093302303#t=article

http://www.mayoclinic.org/diseases-conditions/sickle-cell-anemia/basics/symptoms/con-20019348

http://www.medicinenet.com/sickle_cell/page3.htm

Pictures: 

http://conditions.healthgrove.com/l/919/Sickle-Cell-Anemia

http://www.healthline.com/health/sickle-cell-anemia